The Relay will begin with a grand ceremony held to coincide with Commonwealth Day on the forecourt of Buckingham Palace before the Baton, carrying a special message from The Queen, will set off on a 388-day, 230,000 kilometres journey to the Gold Coast.
The Queen, her husband Prince Philip, the Duke of Edinburgh, and their son Prince Edward, the Earl of Wessex, will send the Baton on its way for a tour of all 70 Commonwealth nations and territories in Africa, the Americas, the Caribbean, Oceania, Asia and Europe before it arrives to spend the final 100 days in Australia.
The message The Queen places in the Baton will be read out at the Opening Ceremony of Gold Coast 2018 on April 4.
The Queen's Baton Relay, a tradition started for the 1958 British Empire and Commonwealth Games in Cardiff, is also due to make an appearance at an interfaith service at Westminster Abbey attended by The Queen and Prince Philip, Prince Charles and his wife Camilla, and Prince Harry and Prince Andrew.
Gold Coast 2018 will be represented by its chairman, former Queensland Premier Peter Beattie, and elders from the Yugambeh people.
The current Queensland Premier, Annastacia Palaszczuk, and Commonwealth Games Federation President Louise Martin will also be attending the ceremony.
Australia's three-time Paralympic gold medallist Kurt Fearnley will deliver the Baton to Buckingham Palace, travelling down The Mall accompanied by the Band of the Scots Guard.
Children and youngsters bearing flags from 70 nations and territories will line the forecourt, while Gold Coast singer Cody Simpson will perform.
Simpson will also perform later at Westminster Abbey.
The Baton's first stop after leaving Buckingham Palace is due to be Sierra Leone.